Napoli lose Arkadiusz Milik to injury, so Dries Mertens, Hirving Lozano and Lorenzo Insigne start against Thiago Motta’s Genoa.
It kicks off at the Stadio San Paolo at 19.45 GMT.
You can follow the build-up and action as it happens from this game and Inter-Verona on the LIVEBLOG.
It has been an extremely tense few days for Napoli, whose players mutinied after a 1-1 draw with RB Salzburg on Tuesday by refusing to go back into the training retreat.
The club ordered a press silence and announced it would take legal action against the players, potentially docking their wages by up to 25 per cent as punishment.
Allan was one of those accused in the media of being behind the rebellion and his home was broken into last night, although the burglars reportedly did not steal anything, just created a mess.
Fans already hurled abuse at the squad during an open training session, with captain Insigne, Allan and Jose Callejon those receiving the most negative attention.
The Brazilian is injured anyway, along with Kostas Manolas, Faouzi Ghoulam and Kevin Malcuit, while Mario Rui is not 100 per cent fit, so Elseid Hysaj starts at left-back.
Milik had been tipped to start, but pulled out of the squad this afternoon with an unspecified injury problem.
Mertens and Chucky Lozano therefore work together, with Insigne and Callejon on the wings.
Genoa already sacked coach Aurelio Andreazzoli to bring in Thiago Motta, with certainly improved performances, but not necessarily much better results, as they are fresh off a 3-1 home defeat to Udinese.
Domenico Criscito, Christian Kouame, Andrea Favilli, Stefano Sturaro and Riccardo Saponara are unavailable, so ex-Napoli veteran Goran Pandev leads the way with Andrea Pinamonti and Kevin Agudelo.
Napoli: Ospina; Di Lorenzo, Maksimovic, Koulibaly, Hysaj; Callejon, Fabian Ruiz, Zielinski, Insigne; Mertens, Lozano
Napoli bench: Meret, Karnezis, Luperto, Tonelli, Mario Rui, Elmas, Gaetano, Younes, Llorente
Genoa: Radu; Pajac, Romero, C Zapata, Ankersen; Lerager, Schone, Cassata; Pandev, Pinamonti, Agudelo
Genoa bench: Marchetti, Jandrei, Barreca, Goldaniga, Sanabria, Gumus, El Yamiq, Biraschi, Jagiello, Ghiglione, Radovanovic, Cleonise
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