Chelsea manager, Thomas Tuchel, has ruled Thiago Silva out of their Premier League clash at Southampton on Saturday.
However, Tammy Abraham and Kai Havertz could both play a part this weekend.
Silva, 36, had missed the Blues’ last three games due to a muscle injury and while the veteran defender trained on Thursday, he is yet to return to full fitness and will not travel for the match.
Havertz picked up a knock ahead of Chelsea’s win at Tottenham earlier this month and has managed just two appearances under Tuchel as a result.
But the 21-year-old attacking midfielder has been passed fit after returning to full training.
There remains a “big question mark” over Christian Pulisic’s availability, with the American forward nursing a minor calf problem.
“We’re very happy that Tammy is very, very good,” Tuchel told reporters at his pre-match press conference on Friday.
“Thiago will be out of the game, he’s not ready for the game.
“And we have some issues with the calf of Christian Pulisic. It’s nothing big, just feels tight and a bit sore is how I understood it yesterday so there’s a big question mark for Christian.
“Kai Havertz is back in training and can join us in Southampton.”
