Inter start Stefano Sensi, Ivan Perisic and Sebastiano Esposito in their final International Champions Cup game with Tottenham Hotspur.
It kicks off in London at 15.06 UK time (14.06 GMT).
Antonio Conte is still missing Lautaro Martinez, Manuel Lazzaro and Diego Godin, while Matteo Politano is only fit for the bench after a muscular problem.
Radja Nainggolan has been loaned to Cagliari and Mauro Icardi is frozen out, so Perisic again has to start as a makeshift striker with 17-year-old youth team player Sebastiano Esposito.
Sensi has impressed in pre-season and takes the midfield reins with Marcelo Brozovic, using Antonio Candreva and Dalbert on the wings.
Tottenham, on the contrary, have an abundance of attacking talent at their disposal, including Harry Kane, Lucas Moura and Erik Lamela, along with summer midfield signing Tanguy Ndombele.
Last season’s Champions League Finalists will begin the Premier League campaign next week.
Tottenham Hotspur: Lloris; Walker-Peters, Sanchez, Vertonghen, Rose; Winks, Sissoko, Ndombele, Lamela; Lucas, Kane
Tottenham bench: Gazzaniga, Whiteman, Austin, Alderweireld, Son, Nkoudou, Eriksen, Georgiou, Marsh, Skipp, Tanganga, Parrott, White
Inter: Handanovic; D’Ambrosio, De Vrij, Skriniar; Candreva, Gagliardini, Brozovic, Sensi, Dalbert; Perisic, Esposito
Inter bench: Padelli, Berni, Dimarco, Ranocchia, Joao Mario, Politano, Borja Valero, Longo, Barella, Agoume, Puscas, Pirola
