Roma start Edin Dzeko, Javier Pastore, Nicolò Zaniolo and Leonardo Spinazzola against Istanbul Basaksehir in the Europa League.
It kicks off at the Stadio Olimpico at 20.00 UK time (19.00 GMT).
You can follow the build-up and action as it happens from this game and Cluj-Lazio on the LIVEBLOG.
The Giallorossi are fresh from their first victory under new Coach Paulo Fonseca, beating Sassuolo 4-2 although they had been 4-0 up after 35 minutes.
However, he completely transforms that line-up, with only Dzeko and Justin Kluivert remaining in attack, joined by Zaniolo and Pastore.
Bryan Cristante and Amadou Diawara form the midfield, with Leonardo Spinazzola moving to right-back.
Cengiz Under, who moved to Roma from Istanbul Basaksehir, cannot face his former club due to an injury.
Chris Smalling, Davide Zappacosta and Diego Perotti are also on the treatment table.
The Turkish team made the trip without former Serie A players Robinho, Gokhan Inler and Martin Skrtel.
Arda Turan and Mehmet Topal are familiar names from the Turkey international squad, while former Arsenal defender Gael Clichy starts at left-back.
Demba Ba has returned to Europe after the former Newcastle United and Chelsea striker had a spell in China, but he is on the bench.
Roma: Pau Lopez; Spinazzola, Fazio, Juan Jesus, Kolarov; Cristante, Diawara; Zaniolo, Pastore, Kluivert; Dzeko
Roma bench: Mirante, Pellegrini, Kalinic, Veretout, Mancini, Florenzi, Mkhitaryan
Istanbul Basaksehir: Günok; Junior Caiçara, Ponck, Tekdemir, Clichy; Aleksic, Mehmet Topal, Kahveci; Visca, Gulbrandsen, Arda Turan
Istanbul bench: Babacan, Epureanu, Ba, Behich, Crivelli, Ugur Ucar, Azubulke
Ref: Estrada Fernandez (SPA)
